Diabetes mellitus, platelet function and acetylsalicylic acid

Diabetes mellitus is an independent risk factor for cardiovascular disease (CVD). Accelerated development of atherosclerosis in patients with diabetes a consequence endothelial dysfunction, low-grade inflammation, oxidative stress, dyslipidemia, and platelet dysfunction. The results studies have shown that among diabetic there high percentage no effect when using both acetylsalicylic acid (ASA) clopidogrel. It necessary to distinguish between weak response people effect— resistant aspirin. frequency the so-called aspirin resistance, according modern research, different depends on methods used study function. In patients, it ranges from 5 45% taking ASA 4 30% Recent show even higher proportion such individuals diabetes. appropriateness lifelong secondary prevention diagnosed CVD indisputable (level evidence A). At same time, approaches primary vary countries. emphasized conditions maintains favorable balance benefits/risks. new guidelines state calculated 10-year events should not be considered deciding whether prescribe without CVD. Instead, all factors present each patient considered, including burdensome family history, inability achieve lipid glycemic levels, coronary calcification. conclusion has evidence-based efficacy prophylaxis been confirmed. Regarding events, healthy individuals, appropriateness, duration administration, choice determined into account serious presence comorbidities, bleeding.